Meta 7 Ingredient Research Library

Browse 120 studies and reviews relating to the individual botanicals and active compounds used in Meta 7. The library includes human clinical research, systematic reviews, animal studies, laboratory work, safety studies and pharmacology papers.

Important evidence notice

These publications investigate individual ingredients, isolated compounds, or combination products. They are not clinical trials of the finished Meta 7 formula. Findings may not apply to Meta 7 because effects depend on the extract, dose, preparation, population and study design.

Showing 120 records

Berberine / Berberis Berberis species / berberine · 25 records
  1. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine
    Human randomised controlled trial Direct ingredient PMID 18397984
  2. Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials
    Systematic review and meta-analysis Direct ingredient PMID 40740996
  3. Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial
    Human randomised clinical trial Direct ingredient PMID 41543854
  4. Effects of administering berberine alone or in combination on type 2 diabetes mellitus: a systematic review and meta-analysis
    Systematic review and meta-analysis Direct and combination evidence PMID 39640489
  5. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension
    Systematic review and meta-analysis Direct ingredient PMID 25498346
  6. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials
    Systematic review and meta-analysis Direct ingredient PMID 23512497
  7. Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients with Mixed Dyslipidemia: A Pilot Clinical Trial
    Human pilot clinical trial Combination evidence PMID 32397850
  8. The Therapeutic Effect of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease: A Meta-Analysis
    Systematic review and meta-analysis Direct ingredient PMID 27446224
  9. Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease
    Human clinical trial Direct ingredient PMID 26252777
  10. Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion
    Human randomised controlled trial Direct ingredient PMID 23808999
  11. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis
    Systematic review and meta-analysis Direct ingredient PMID 23118793
  12. Efficacy of berberine in patients with type 2 diabetes mellitus
    Human clinical trial Direct ingredient PMID 18442638
  13. Effects of berberine on glucose-lipid metabolism, inflammatory factors and insulin resistance in patients with metabolic syndrome
    Human clinical trial Direct ingredient PMID 30936971
  14. Pilot study on the efficacy and safety of berberine in people with metabolic syndrome and human immunodeficiency virus infection
    Human pilot randomised trial Direct ingredient PMID 37611246
  15. Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
    Systematic review and meta-analysis Direct ingredient PMID 33981233
  16. Efficacy and safety of berberine for dyslipidaemias: A systematic review and meta-analysis of randomized clinical trials
    Systematic review and meta-analysis Direct ingredient PMID 30466986
  17. The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial
    Human randomised clinical trial Combination evidence PMID 39998703
  18. The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
    Systematic review and meta-analysis Direct ingredient PMID 38429794
  19. The Effect of Berberine on Lipid Profile, Liver Enzymes, and Fasting Blood Glucose in Patients with Non-alcoholic Fatty Liver Disease (NAFLD): A Randomized Controlled Trial
    Human randomised controlled trial Direct ingredient PMID 36128280
  20. Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Systematic review and meta-analysis Direct ingredient PMID 37598753
  21. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials
    Systematic review and meta-analysis Direct ingredient PMID 36941490
  22. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Systematic review and meta-analysis Direct ingredient PMID 34956436
  23. Effects of berberine on blood glucose in patients with type 2 diabetes mellitus: a systematic literature review and a meta-analysis
    Systematic review and meta-analysis Direct ingredient PMID 30393248
  24. Adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia: a randomized controlled trial
    Human randomised controlled trial Adjunctive evidence PMID 34931749
  25. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
    Animal and cell mechanistic study Direct ingredient PMID 16873688
Fenugreek Trigonella foenum-graecum · 20 records
  1. The effect of the fenugreek hydrolyzed protein on lipid profile in patients with mild-to-moderate hypercholesterolemia: A confirmatory triple-blind randomized-controlled clinical trial
    Human randomised controlled trial Direct ingredient PMID 39935620
  2. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study
    Human randomised controlled trial Direct ingredient PMID 11868855
  3. The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Systematic review and meta-analysis Direct ingredient PMID 37762302
  4. Effect of fenugreek consumption on serum lipid profile: A systematic review and meta-analysis
    Systematic review and meta-analysis Direct ingredient PMID 32385866
  5. Effect of Fenugreek Seeds on Serum Metabolic Factors and Adiponectin Levels in Type 2 Diabetic Patients
    Human clinical trial Direct ingredient PMID 26098483
  6. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
    Systematic review and meta-analysis Direct ingredient PMID 27496582
  7. A randomized double blind placebo controlled trial to assess the safety and efficacy of a patented fenugreek (Trigonella foenum-graecum) seed extract in Type 2 diabetics
    Human randomised controlled trial Direct ingredient PMID 38863744
  8. The effect of Fenugreek seed dry extract supplement on glycemic indices, lipid profile, and prooxidant-antioxidant balance in patients with type 2 diabetes: A double-blind randomized clinical trial
    Human randomised controlled trial Direct ingredient PMID 39430281
  9. The effects of fenugreek (Trigonella foenum-graecum) seed on glycemic parameters: An updated systematic review and meta-analysis of randomized controlled trials
    Systematic review and meta-analysis Direct ingredient PMID 41509111
  10. The Effects of Fenugreek on Cardiometabolic Risk Factors in Adults: A Systematic Review and Meta-analysis
    Systematic review and meta-analysis Direct ingredient PMID 32951700
  11. Effect of Fenugreek on Hyperglycemia: A Systematic Review and Meta-Analysis
    Systematic review and meta-analysis Direct ingredient PMID 36837450
  12. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes
    Human randomised clinical trial Direct ingredient PMID 2194788
  13. Effect of fenugreek supplementation on blood lipids and body weight: A systematic review and meta-analysis of randomized controlled trials
    Systematic review and meta-analysis Direct ingredient PMID 32087319
  14. A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
    Human randomised controlled trial Comparative evidence PMID 31148988
  15. A simple dietary addition of fenugreek seed leads to the reduction in blood glucose levels: A parallel group, randomized single-blind trial
    Human randomised clinical trial Direct ingredient PMID 29861588
  16. Effect of Fenugreek Use on Fasting Blood Glucose, Glycosylated Hemoglobin, Body Mass Index, Waist Circumference, Blood Pressure and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trials
    Human randomised controlled trial Direct ingredient PMID 34466512
  17. Effect of fenugreek fiber on satiety, blood glucose and insulin response and energy intake in obese subjects
    Human feeding trial Direct ingredient PMID 19353539
  18. Hypocholesterolemic effect of germinated fenugreek seeds in human subjects
    Human study Direct ingredient PMID 10540988
  19. Therapeutic effect of fenugreek supplementation on type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials
    Systematic review and meta-analysis Direct ingredient PMID 39286181
  20. Fenugreek bread: a treatment for diabetes mellitus
    Human crossover feeding trial Direct ingredient PMID 19857068
Bitter melon Momordica charantia · 20 records
  1. Effects of Momordica charantia L. supplementation on glycemic control and lipid profile in type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
    Systematic review and meta-analysis Direct ingredient PMID 38784554
  2. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study
    Human randomised clinical trial Direct ingredient PMID 37009042
  3. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus
    Human randomised controlled trial Direct ingredient PMID 32951763
  4. The metabolic effect of Momordica charantia cannot be determined based on the available clinical evidence: a systematic review and meta-analysis of randomized clinical trials
    Systematic review and meta-analysis Direct ingredient PMID 38274207
  5. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies
    Human randomised controlled trial Direct ingredient PMID 17493509
  6. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant source
    Human clinical trial Direct ingredient PMID 20078273
  7. Efficacy of Momordica charantia in glycaemic control and insulin resistance among patients with prediabetes and type 2 diabetes. A GRADE-adherent meta-analysis of randomised controlled trials
    Systematic review and meta-analysis Direct ingredient PMID 41280283
  8. A randomized, double-blind, placebo-controlled trial to evaluate the hypoglycemic efficacy of the mcIRBP-19-containing Momordica charantia L. fruit extracts in the type 2 diabetic subjects
    Human randomised controlled trial Direct ingredient PMID 35140559
  9. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis
    Systematic review and meta-analysis Direct ingredient PMID 30385422
  10. Effect of Momordica charantia Administration on Anthropometric Measures and Metabolic Profile in Patients with Obesity: A Pilot Clinical Trial
    Human pilot clinical trial Direct ingredient PMID 35507955
  11. Antihyperglycemic effects of three extracts from Momordica charantia
    Preclinical study Direct ingredient PMID 12902059
  12. Bitter gourd (Momordica charantia L.) supplementation for twelve weeks improves biomarkers of glucose homeostasis in a prediabetic population
    Human randomised controlled trial Direct ingredient PMID 40199408
  13. Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet
    Animal study Direct ingredient PMID 18550200
  14. Cucurbitane Triterpenoids from the Fruits of Momordica Charantia Improve Insulin Sensitivity and Glucose Homeostasis in Streptozotocin-Induced Diabetic Mice
    Animal and cell study Direct compounds PMID 29405623
  15. The effects of bitter melon (Momordica charantia) on anthropometric indices in adults: A systematic review and meta-analysis of randomized controlled trials
    Systematic review and meta-analysis Direct ingredient PMID 39079610
  16. Bitter melon fruit extract has a hypoglycemic effect and reduces hepatic lipid accumulation in ob/ob mice
    Animal study Direct ingredient PMID 31845444
  17. Bitter melon extract ameliorates palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 cells and high-fat/high-fructose-diet-induced fatty liver
    Animal and cell study Direct ingredient PMID 30026676
  18. Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions
    Animal study Direct ingredient PMID 18321395
  19. Momordica charantia ameliorates insulin resistance and dyslipidemia with altered hepatic glucose production and fatty acid synthesis and AMPK phosphorylation in high-fat-fed mice
    Animal study Direct ingredient PMID 23610006
  20. Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet
    Animal study Direct ingredient PMID 12672924
Gymnema Gymnema sylvestre · 20 records
  1. An evidence-based systematic review of gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration
    Systematic review Direct ingredient PMID 22432729
  2. A systematic review of Gymnema sylvestre in obesity and diabetes management
    Systematic review Direct ingredient PMID 24166097
  3. Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
    Human randomised controlled trial Direct ingredient PMID 28459647
  4. Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance
    Human randomised controlled trial Direct ingredient PMID 32460589
  5. The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis
    Systematic review and meta-analysis Direct ingredient PMID 34467577
  6. The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta-analysis
    Systematic review and meta-analysis Direct ingredient PMID 36580574
  7. Efficacy and Tolerability of a Food Supplement Based on Zea mays L., Gymnema sylvestre (Retz.) R.br.ex Sm, Zinc and Chromium for the Maintenance of Normal Carbohydrate Metabolism: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
    Human randomised controlled trial Combination evidence PMID 39125340
  8. Gymnemic Acid Alleviates Type 2 Diabetes Mellitus and Suppresses Endoplasmic Reticulum Stress in Vivo and in Vitro
    Animal and cell study Direct compound PMID 30864442
  9. The effect of a 14-day Gymnema sylvestre intervention to reduce sugar intake in people self-identifying with a sweet tooth
    Human intervention trial Direct ingredient PMID 39855349
  10. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability
    Cell study Direct ingredient PMID 10556769
  11. A novel Gymnema sylvestre extract protects pancreatic beta-cells from cytokine-induced apoptosis
    Cell study Direct ingredient PMID 31515869
  12. Gymnemic acid alleviates inflammation and insulin resistance via PPARδ- and NFκB-mediated pathways in db/db mice
    Animal study Direct compound PMID 31464308
  13. Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study
    Human randomised study Comparative evidence PMID 39064727
  14. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus
    Human clinical study Direct ingredient PMID 2259216
  15. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients
    Human clinical study Direct ingredient PMID 2259217
  16. The Effect of a 14-Day gymnema sylvestre Intervention to Reduce Sugar Cravings in Adults
    Human randomised controlled trial Direct ingredient PMID 36558446
  17. Inhibition of the sweet taste by Gymnema sylvestre
    Human clinical study Direct ingredient PMID 5792442
  18. Gymnema Sylvestre Supplementation Restores Normoglycemia, Corrects Dyslipidemia, and Transcriptionally Modulates Pancreatic and Hepatic Gene Expression in Alloxan-Induced Hyperglycemic Rats
    Animal study Direct ingredient PMID 37110174
  19. Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice
    Animal study Direct compound PMID 11249615
  20. Possible regeneration of the islets of Langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts
    Animal study Direct ingredient PMID 2259215
Black pepper / piperine Piper nigrum / piperine · 15 records
  1. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
    Human and animal pharmacokinetic study Combination evidence PMID 9619120
  2. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
    Human randomised trial and meta-analysis Combination evidence PMID 25618800
  3. Piperine attenuates hepatic steatosis and insulin resistance in high-fat diet-induced obesity in Sprague-Dawley rats
    Animal study Direct compound PMID 36375392
  4. Piperine, an LXRα antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat diet
    Animal study Direct compound PMID 23000915
  5. The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial
    Human randomised controlled trial Direct compound PMID 38200253
  6. Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats
    Animal study Direct compound PMID 22038304
  7. Piperine ameliorates insulin resistance via inhibiting metabolic inflammation in monosodium glutamate-treated obese mice
    Animal study Direct compound PMID 33028294
  8. Piperine Improves Obesity by Inhibiting Fatty Acid Absorption and Repairing Intestinal Barrier Function
    Animal and mechanistic study Direct compound PMID 34591253
  9. Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 cells
    Cell study Direct compound PMID 22463744
  10. Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages
    Cell study Direct compound PMID 18520030
  11. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial
    Human randomised controlled trial Combination evidence PMID 25440375
  12. Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial
    Human randomised controlled trial Combination evidence PMID 29458218
  13. The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia
    Human randomised controlled trial Combination evidence PMID 39165011
  14. A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications
    Systematic review Direct ingredient PMID 30740986
  15. Therapeutic spectrum of piperine for clinical practice: a scoping review
    Scoping review Direct compound PMID 34996326
Bitter kola Garcinia kola / kolaviron · 10 records
  1. Kolaviron improved resistance to oxidative stress and inflammation in the blood (erythrocyte, serum, and plasma) of streptozotocin-induced diabetic rats
    Animal study Direct extract PMID 24795542
  2. Ethanol extract of Garcinia kola seeds alleviates HGHFD/STZ-induced nonalcoholic fatty liver disease in diabetic rats by modulating oxidative stress, inflammation, and lipid accumulation
    Animal study Direct extract PMID 40666176
  3. Kolaviron, a biflavonoid complex of Garcinia kola seeds modulates apoptosis by suppressing oxidative stress and inflammation in diabetes-induced nephrotoxic rats
    Animal study Direct extract PMID 25481391
  4. A review on garcinia kola heckel: traditional uses, phytochemistry, pharmacological activities, and toxicology
    Narrative review Direct ingredient PMID 34904497
  5. Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats
    Animal study Direct extract PMID 15730433
  6. Mechanisms for the hepatoprotective action of kolaviron: studies on hepatic enzymes, microsomal lipids and lipid peroxidation in carbontetrachloride-treated rats
    Animal study Direct extract PMID 10860638
  7. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses
    Animal study Direct extract PMID 24359406
  8. Garcinia kola seed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats
    Animal study Direct ingredient PMID 25243878
  9. Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats
    Animal study Direct extract PMID 23515095
  10. Kolaviron modulates dysregulated metabolism in oxidative pancreatic injury and inhibits intestinal glucose absorption with concomitant stimulation of muscle glucose uptake
    Cell and preclinical study Direct extract PMID 32799570
Abere Picralima nitida · 10 records
  1. Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (Apocynaceae) and Sonchus oleraceus (Asteraceae)
    Preclinical study Mixed-plant evidence PMID 23855679
  2. Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferation
    Animal study Mixed-plant evidence PMID 23565805
  3. Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats
    Animal study Direct ingredient PMID 33163962
  4. Screening of the seed of Picralima nitida for hypoglycaemic activity
    Animal study Direct ingredient PMID 19069874
  5. Alpha-Amylase Inhibition and Antioxidative Capacity of Some Antidiabetic Plants Used by the Traditional Healers in Southeastern Nigeria
    Cell and enzyme study Mixed-plant evidence PMID 28367491
  6. Medicinal uses, phytochemistry and pharmacology of Picralima nitida (Apocynaceae) in tropical diseases: a review
    Narrative review Direct ingredient PMID 24418074
  7. Picralima nitida leaf extract ameliorates oxidative stress and modulates insulin signaling pathway in high fat-diet/STZ induced diabetic rats
    Animal study Direct ingredient DOI 10.1016/j.sajb.2022.04.048
  8. Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids
    Cell and pharmacology study Direct compounds PMID 33326237
  9. Toxicological evaluation of Picralima nitida in rodents
    Animal safety study Direct ingredient PMID 30853649
  10. Potential inhibition of major human cytochrome P450 isoenzymes by selected tropical medicinal herbs-Implication for herb-drug interactions
    Cell interaction study Mixed-plant evidence PMID 30680158
Research transparency:

Inclusion does not mean that every study showed a positive outcome, nor that the finished Meta 7 formula has been clinically proven to diagnose, prevent, treat or cure a disease. Open the original record and assess the full paper and its limitations.